Box 2

Description Neurobiological studies of Drosophila were focused on; Studies focusing on cell differentiation in Moss, Zebra fish and slime molds (Dictyostelium discoideum) were conducted; Mutation found in bithorax complexes was identified; Antibody that functions as female Drosophila antenna marker was identified; Work done in the laboratory of E.Buchner at the Max-Planck Institute on Olfactory centres was followed up on; A mutation involved in the metathoracic transformation resembling that reported by...

Description Based on findings by the Solid State Physics Group , studies on the binding and regulation of brain hexokinase were carried out; The glycolysis in yeast was studied with respect to Particulate fructokinase and aldolases; Highlights : O.Siddiqi-Awarded Indian National Science Golden Jubilee Medal; R.N.Singh was at sabbatical at Yale University, USA for a year; V.Nanjundaiah was on leave at the University of Kyoto for a year; Summary: Yeast glycolytic pathway was intensively studied with much...

Description Perception of salts by Drosophila were studied, distinct receptor sites were found; two genes coding for enzyme pyruvate decarboxylase were found, one of them was successfully cloned; neurons were being labelled using horseradish peroxide or cobalt(II) ; molecular analysis of two muscle mutants were initiated; cDNA cloning was done in collaboration with M.A.Palazzo and S.Celniker at Caltech; plant hormone studies using moss (F. hygrometrica); Peptide mapping comparing human and Drosophila...

Description Drosophila neurobiology- chemosensory and neural pathways identified, olf E gene characterisation was begun; Drosophila neuroanatomy- Golgi silver impregnation used for neural fibre identification, horseradish peroxide markers used, pattern of flight muscles were studied, cDNA collaboration with Caltech; Cell Differentiation-(F. hygrometrica-moss)auxin sensitivity, Nitrate reductase immunoassay, Drosophila oncogenes were studied using E.coli, Saccharomyces cerevisiae(a type of yeast) was...

Description Drosophila Neurobiology- muscle development, gustatory pathway, horseradish peroxide uptake by neurons, sensory fibres in antenna, synaptogenesis was studied in embryos; Study using the moss, protonema, of auxin role in cell differentiation between caulonema and chloronema states; G proteins; Drosophila proto oncogenes; Glycolysis in yeast- (Saccharomyces cerevisiae) Aldolase suppression, PDC2; Malarial Parasite-(P.falciparum-obtained from Gujarat and Delhi, P.vivax, P.knowlesi) immunogenic...

Description Neurobiology of Drosophila- 'chromosome walking' methods appear to be used: it was found that closely related flight muscles develop differently, collaboration with W.Chia at University of Singapore for research on gustation. Cloned cDNA work in collaboration with Caltech and U.C.Berkeley, olfaction; Synaptic Biology- anaesthetics studied by K.S.Krishnan on work leave (work with A.H.Nash); Neuroanatomy Drosophila-sensory structures on the leg, peripheral synapse present in femoral...

Description Neurobiology Drosophila-flight muscles, chemosensory genes, collaboration with IMCB, Singapore for gustation behaviour, olfE gene associated with learning and memory, neural uptake of horseradish peroxidase technique used to identify sensory fibres, serine proteases, IP3 pathway; Drosophila neuroanatomy- Transmission Electron Microscope used to study development during pupation, synaptogenesis, femur glomerulus; Molecular neurobiology-(E. coli) cloned human potassium channel cDNA,...

Description Drosophila neurobiology-cell differentiation, flight muscles, nervous system changes with metamorphosis, proneural genes in proboscis and antenna, collaboration for cDNA clones in Brandeis University, collaboration for chemosensation genetics with University of Singapore; Synapse Cell Biology -(Drosophila)halothane anaesthesia ( Challenges Unitary Target Hypothesis),shibire interactions, vesicle recycling ; Neuroanatomy-Feeding and Gustation; Hormone signalling ( Funaria hygrometrica- moss),...

Description Drosophila neurobiology-anatomy and physiology were studied(Bombay and NCBS collaboration); Synapse Cell Biology -(Drosophila)halothane anaesthesia studies were done, shibire mutation was explored; Neuroanatomy-(Supella longipalpa-cockroach)GAS sensillium discovered; Recombination- Chlamydomonas model used; Biochemistry and Molecular biology-(Yeast) role of 'Aspargine bridge' in pyruvate decarboxylase, (Funaria hygrometrica-Moss) protein kinase, CAM, (moss, corn, sorghum) G-Protein; Malarial...

Description Neurobiology Drosophila-programmed cell death, anaesthetic action, taste and olfactory pathways, antennal studies, chemosensation; Biochemistry and Molecular Biology -( moss, corn, sorghum)auxin binding, CAM, G proteins were studied ,(chlamydomonas)recombination in plants; Yeast Molecular biology-(S. pombe)glycolytic shunt pathway; Molecular Biology for Malarial Parasite-(P. falciparum, P. vivax, P. knowlesi) cDNA, CS antigen, (rabbit models used);; 8 research groups,...

Description Neurobiology of Drosophila-proneural genes for Olfaction, antennal development, loop helix encoding gene, Drosophila obtained from Bloomington, Indiana;Cell biology of Synapse- Shibire enhancers and Endocytosis was studied, Anaesthetic action was explored; Plant Biology- enzyme receptors were studied ; Malarial Parasite-(Plasmodium falciparum, P. berghei, P. vivax) natural immunity was explored and found to be caused by the P0 gene, CS antigen, lack of Rhesus monkey test subjects; Yeast...

Description Neurobiology of Drosophila-Olfaction and antennal development ;Genetics and Cell biology of Synapse- Vesicle Cycle, Anaesthetic action (challenging the Unitary Target Hypothesis) and Neuro Spinal Fluid development; Plant Biology- the action of plant growth enhancers were studied; Malarial Parasite- immunity antigens (P0); Carbohydrate metabolism- (Yeast)Sugar transport mutants ; Molecular repair and recombination- (Chlamydomonas and E.Coli) Rec A reactions;;9 research groups; structural cell...